Characterization and Bioavailability of Tea Polyphenol Nanoliposome Prepared by Combining an Ethanol Injection Method with Dynamic High-Pressure Microfluidization

Tea polyphenols are major polyphenolic substances found in green tea with various biological activities. To overcome their instability toward oxygen and alkaline environments, tea polyphenol nanoliposome (TPN) was prepared by combining an ethanol injection method with dynamic high-pressure microflui...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2014-01, Vol.62 (4), p.934-941
Main Authors: Zou, Li-qiang, Liu, Wei, Liu, Wei-lin, Liang, Rui-hong, Li, Ti, Liu, Cheng-mei, Cao, Yan-lin, Niu, Jing, Liu, Zhen
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
antioxidant activity
Antioxidants - pharmacology
bioavailability
Biological Availability
Drug Stability
Ethanol
free radical scavengers
green tea
Liposomes
Listeria monocytogenes
Nanocapsules
oxygen
Particle Size
polyphenols
Polyphenols - administration & dosage
Polyphenols - pharmacokinetics
Polyphenols - pharmacology
Pressure
Salmonella Typhimurium
Staphylococcus aureus
Tea - chemistry
Technology, Pharmaceutical - methods
zeta potential
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Summary:Tea polyphenols are major polyphenolic substances found in green tea with various biological activities. To overcome their instability toward oxygen and alkaline environments, tea polyphenol nanoliposome (TPN) was prepared by combining an ethanol injection method with dynamic high-pressure microfluidization. Good physicochemical characterizations (entrapment efficiency = 78.5%, particle size = 66.8 nm, polydispersity index = 0.213, and zeta potential = −6.16 mv) of TPN were observed. Compared with tea polyphenol solution, TPN showed equivalent antioxidant activities, indicated by equal DPPH free radical scavenging and slightly lower ferric reducing activities and lower inhibitions against Staphylococcus aureus, Escerhichia coli, Salmonella typhimurium, and Listeria monocytogenes. In addition, a relatively good sustained release property was observed in TPN, with only 29.8% tea polyphenols released from nanoliposome after 24 h of incubation. Moreover, TPN improved the stability of tea polyphenol in alkaline solution. This study expects to provide theories and practice guides for further applications of TPN.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf402886s