Copper-Catalyzed Oxyazidation of Unactivated Alkenes: A Facile Synthesis of Isoxazolines Featuring an Azido Substituent

A novel and efficient Cu(OAc)2-catalyzed oxyazidation of unactivated alkenes was developed. The reactions are easy to conduct, occur under mild conditions, and form azido-substituted isoxazolines in good yields.

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Bibliographic Details
Published in:Organic letters 2014-03, Vol.16 (6), p.1562-1565
Main Authors: Zhu, Liping, Yu, Hongmei, Xu, Zhaoqing, Jiang, Xianxing, Lin, Li, Wang, Rui
Format: Article
Language:English
Subjects:
Alkenes - chemistry
Azides - chemistry
Catalysis
Copper - chemistry
Isoxazoles - chemical synthesis
Isoxazoles - chemistry
Molecular Structure
Stereoisomerism
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Description
Summary:A novel and efficient Cu(OAc)2-catalyzed oxyazidation of unactivated alkenes was developed. The reactions are easy to conduct, occur under mild conditions, and form azido-substituted isoxazolines in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol403687k