The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients

Abstract Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portug...

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Bibliographic Details
Published in:Journal of neuroimmunology 2014-04, Vol.269 (1), p.52-55
Main Authors: Bettencourt, Andreia, Silva, Ana Martins, Carvalho, Cláudia, Leal, Bárbara, Santos, Ernestina, Costa, Paulo P, Silva, Berta M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergy and Immunology
Child
Cohort Studies
Female
Humans
KIR
Male
Middle Aged
Multiple Sclerosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - genetics
Multiple Sclerosis - metabolism
Natural killer cells
Neurology
Portugal
Portugal - epidemiology
Receptors, KIR - genetics
Receptors, KIR - metabolism
Young Adult
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Summary:Abstract Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. We observed a negative association between the activating KIR2DS1 gene and MS (adjusted OR = 0.450, p = 0.030) independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2014.01.009