Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: A case report

Abstract The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensi...

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Bibliographic Details
Published in:Human immunology 2014-05, Vol.75 (5), p.462-465
Main Authors: Cippà, Pietro E, Gaspert, Ariana, Etter, Christoph, Guenduez, Zehra, Ferrari-Lacraz, Sylvie, Rüsi, Barbara, Fehr, Thomas
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies - blood
Antibodies - immunology
Antibody-Dependent Cell Cytotoxicity - immunology
Biopsy
Graft Rejection - immunology
HLA-DP Antigens - immunology
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - immunology
Kidney Failure, Chronic - pathology
Kidney Failure, Chronic - therapy
Kidney Glomerulus - pathology
Kidney Transplantation - adverse effects
Male
Middle Aged
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Summary:Abstract The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2014.02.008