Visualizing the atherosclerotic plaque: a chemical perspective

Atherosclerosis is the major underlying pathologic cause of coronary artery disease. An early detection of the disease can prevent clinical sequellae such as angina, myocardial infarction, and stroke. The different imaging techniques employed to visualize the atherosclerotic plaque provide informati...

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Bibliographic Details
Published in:Chemical Society reviews 2014-04, Vol.43 (8), p.2858-2876
Main Authors: Teresa Albelda, M a, Garcia-España, Enrique, Frias, Juan C
Format: Article
Language:English
Subjects:
Atherosclerosis
Contrast agents
Contrast Media - chemistry
Coordination Complexes - chemistry
Coronary Artery Disease - diagnosis
Coronary Artery Disease - diagnostic imaging
Diagnostic systems
Gadolinium - chemistry
Human
Humans
Imaging
Imaging techniques
Information dissemination
Iron - chemistry
Magnetic Resonance Imaging
Myocardial infarction
Organotechnetium Compounds - chemistry
Plaque, Atherosclerotic - pathology
Positron-Emission Tomography
Tomography, X-Ray Computed
Ultrasonography
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Summary:Atherosclerosis is the major underlying pathologic cause of coronary artery disease. An early detection of the disease can prevent clinical sequellae such as angina, myocardial infarction, and stroke. The different imaging techniques employed to visualize the atherosclerotic plaque provide information of diagnostic and prognostic value. Furthermore, the use of contrast agents helps to improve signal-to-noise ratio providing better images. For nuclear imaging techniques and optical imaging these agents are absolutely necessary. We report on the different contrast agents that have been used, are used or may be used in future in animals, humans, or excised tissues for the distinct imaging modalities for atherosclerotic plaque imaging. Compounds and imaging techniques used to visualize the atherosclerotic plaque, one of the major pathologies causing coronary artery diseases, are discussed.
ISSN:0306-0012
1460-4744
DOI:10.1039/c3cs60410a