Prostatectomy v radiotherapy: possible detrimental effect of hormonal manipulation in patients receiving radiotherapy

Evidence that surgery is more effective than radiotherapy at prolonging life in men with prostate cancer has been growing since the 1997 seminal study of 59876 men, 1 through two studies of 471691, 2 3 to Sooriakumaran and colleagues' current paper, 4 which also tackles head-on the problem of c...

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Bibliographic Details
Published in:BMJ (Online) 2014-03, Vol.348 (mar25 10), p.g2273-g2273
Main Author: Eden, Christopher G
Format: Article
Language:English
Subjects:
Cancer therapies
Forecasting
Humans
Male
Mortality
Prostate cancer
Prostatectomy - methods
PROSTATECTOMY V RADIOTHERAPY
Prostatic Neoplasms - radiotherapy
Radiation therapy
Surgery
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Summary:Evidence that surgery is more effective than radiotherapy at prolonging life in men with prostate cancer has been growing since the 1997 seminal study of 59876 men, 1 through two studies of 471691, 2 3 to Sooriakumaran and colleagues' current paper, 4 which also tackles head-on the problem of confounding factors.Improvements include the use of extended pelvic lymphadenectomy in men with intermediate and high risk prostate cancer, which increased cancer specific survival of men in these risk groups seven years after surgery by 12.6% and 20.3%, respectively, in a randomised controlled trial. 5 The difference in the effectiveness of radiotherapy and surgery may not lie just in their biological and physical effects.
ISSN:0959-8138
1756-1833
1756-1833
DOI:10.1136/bmj.g2273