Xenobiotic metabolizing enzyme systems in test fish: 3. Comparative studies of liver cytosolic glutathione S-transferases

The reduced glutathione (GSH)-conjugating capacities of the livers of zebra fish (Brachidanio rerio ), common carp (Cyprinus carpio ), rainbow trout (Salmo gairdneri ), bluegill (Lepomis macrochirus ), and guppy (Poecilia reticulata ) have been evaluated with several substrates preferentially metabo...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 1988-10, Vol.16 (2), p.180-186
Main Authors: Donnarumma, L, De Angelis, G, Gramenzi, F, Vittozzi, L
Format: Article
Language:English
Subjects:
Cyprinus carpio
Freshwater
Lepomis macrochirus
Poecilia reticulata
Online Access:Get full text
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Summary:The reduced glutathione (GSH)-conjugating capacities of the livers of zebra fish (Brachidanio rerio ), common carp (Cyprinus carpio ), rainbow trout (Salmo gairdneri ), bluegill (Lepomis macrochirus ), and guppy (Poecilia reticulata ) have been evaluated with several substrates preferentially metabolized by the major GSH-transferase isozymes. Carp and zebra fish lack GSH-transferase activity with 1,2-epoxy-3-(p-nitrophenoxy)propane. Guppy is characterized by the highest activities with 1-chloro-2,4-dinitrobenzene and the absence of activity toward trans-4-phenyl-3-buten-2-one. Enzyme activities with the other substrates demonstrate quantitative interspecific differences which presumably are of minor relevance to the metabolism and toxicity of chemicals.
ISSN:0147-6513
DOI:10.1016/0147-6513(88)90033-4