Experimental and human surveillance on BHC and DDT insecticides commonly used in India

The present study was planned to evaluate the carcinogenicity in laboratory animals of these chlorinated insecticides, DDT and BHC, (technical grade) commonly used in India. The in-depth histopathologic, histochemical and biochemical changes during the process of hepatocarcinogenesis induced by BHC...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1988, Vol.534 (1), p.694-705
Main Authors: Nigam, S.K. (National Institute of Occupational Health, Ahmedabad, India), Karnik, A.B, Lakkad, B.C, Thakore, K.N, Joshi, B.H
Format: Article
Language:English
Subjects:
Adult
Animals
CARCINOMA
CARCINOME
DDT - analysis
DDT - toxicity
Environmental Monitoring
HCH
Hexachlorocyclohexane - analysis
Hexachlorocyclohexane - toxicity
HISTOCHEMISTRY
HISTOPATHOLOGY
Humans
INDE
INDIA
INSECTICIDAS
INSECTICIDE
INSECTICIDES
Isomerism
Liver - drug effects
Liver - enzymology
Male
MICE
OBREROS
OCCUPATIONAL HAZARDS
OUVRIER
RATON
RESIDU
RESIDUES
RESIDUOS
RIESGOS OCUPACIONALES
RISQUE PROFESSIONNEL
SOURIS
WORKERS
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Summary:The present study was planned to evaluate the carcinogenicity in laboratory animals of these chlorinated insecticides, DDT and BHC, (technical grade) commonly used in India. The in-depth histopathologic, histochemical and biochemical changes during the process of hepatocarcinogenesis induced by BHC were also studied to find out the early sequential events leading to the genesis of liver cancer. In addition, cytogenetic studies were also carried out to evaluate the effect of BHC feeding on mitotic and meiotic divisions. Since the gamma isomer (Lindane) is the active principle, possessing insecticidal properties in technical BHC, its carcinogenic activity was also studied and compared with that of technical BHC.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1988.tb30159.x