Urinary excretion kinetics of p-nitrophenol following oral administration of parathion in the rabbit

The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h af...

Full description

Saved in:
Bibliographic Details
Published in:Archives of toxicology 1988, Vol.62 (5), p.351-354
Main Authors: Pena-Egido, M.J, Marino-Hernandez, E.L, Santos-Buelga, C, Rivas-Gonzalo, J.C
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological and medical sciences
excretion
intake
kinetics
Male
Medical sciences
metabolism
Nitrophenols - urine
parathion
Parathion - pharmacokinetics
Parathion - toxicity
Pesticides, fertilizers and other agrochemicals toxicology
Rabbits
Toxicology
urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The urinary excretion kinetics of p-nitrophenol were studied in rabbits following oral administration of parathion at a dose of 3 mg/kg. Elimination of p-nitrophenol began rapidly, and of the total amount excreted during the study period, 46% was excreted in the first 3 h; 85% was excreted at 6 h after administration of the pesticide. The mean maximum excretion rate of p-nitrophenol was 111.15 +/- 61.02 micrograms/h reached in a time of 0.77 +/- 0.26 h. The formation and disappearance rate constants of the metabolite were 2.85 +/- 2.80 h-1 and 0.80 +/- 0.28 h-1, respectively. A linear relationship was observed between the plasma concentrations of parathion and the urinary excretion rate of p-nitrophenol.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00293622