Acute regulation of hematocrit and acid–base balance in chicken embryos in response to severe intrinsic hypercapnic hypoxia

Highlights • Water submersion produced intrinsic hypercapnic hypoxia in chick embryos. • There was a progressive hysteresis in acid–base disturbance during submersion and recovery in air. • Swift blood lactate changes due to anaerobic glycolysis drive acid–base disturbances. • Swift Hct changes resu...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2014-05, Vol.195, p.1-10
Main Authors: Andrewartha, Sarah J, Tazawa, Hiroshi, Burggren, Warren W
Format: Article
Language:English
Subjects:
Acid-Base Equilibrium
Acid-Base Imbalance - physiopathology
Acid–base balance
Animals
Chick Embryo
Chicken embryo
Erythrocyte Indices
Erythrocytes - pathology
Erythrocytes - physiology
Hct
Hematocrit
Hypercapnia - pathology
Hypercapnia - physiopathology
Hypoxia - pathology
Hypoxia - physiopathology
Immersion
Lactate
Lactic Acid - blood
Medical Education
Osmolar Concentration
Oxygen Consumption
Pulmonary/Respiratory
Severe intrinsic hypoxia
Survival Analysis
Time Factors
Water submersion
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Summary:Highlights • Water submersion produced intrinsic hypercapnic hypoxia in chick embryos. • There was a progressive hysteresis in acid–base disturbance during submersion and recovery in air. • Swift blood lactate changes due to anaerobic glycolysis drive acid–base disturbances. • Swift Hct changes result from proportional increases in red blood cell volume and concentration. • A short severe intrinsic hypercapnic hypoxia does not compromise viability of embryos.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.01.019