The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study

Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease...

Full description

Saved in:
Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2014-04, Vol.252 (4), p.619-626
Main Authors: Celebi, Ali Riza Cenk, Ulusoy, Cemalettin, Mirza, G. Ertugrul
Format: Article
Language:English
Subjects:
Administration, Topical
Cornea
Cornea - metabolism
Cornea - physiopathology
Cross-Over Studies
Double-Blind Method
Dry Eye Syndromes - physiopathology
Dry Eye Syndromes - therapy
Female
Fluorescein - metabolism
Fluorophotometry
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmic Solutions
Ophthalmology
Preservatives, Pharmaceutical - administration & dosage
Prospective Studies
Serum - physiology
Tears - physiology
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer’s Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT ( P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-014-2599-1