A charge-switchable, four-armed polymeric photosensitizer for photodynamic cancer therapy

A water-soluble, charge-switchable, four-armed polymeric photosensitizer (C4P-PS), in which charge switching is pH dependent, has been designed as a new class of photosensitizer for photodynamic cancer therapy.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-04, Vol.50 (33), p.4354-4357
Main Authors: Lee, Chung-Sung, Park, Wooram, Jo, Young Um, Na, Kun
Format: Article
Language:English
Subjects:
Animals
Cell Survival - drug effects
HCT116 Cells
Humans
Hydrogen-Ion Concentration
Lasers
Mice
Mice, Nude
Neoplasms - drug therapy
Photochemotherapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Polymers - chemistry
Porphyrins - chemistry
Porphyrins - pharmacology
Porphyrins - therapeutic use
Transplantation, Heterologous
Water - chemistry
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Description
Summary:A water-soluble, charge-switchable, four-armed polymeric photosensitizer (C4P-PS), in which charge switching is pH dependent, has been designed as a new class of photosensitizer for photodynamic cancer therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc00746h