Acute immune hematological complication of oxaliplatin. A series of 3 cases

We report a series of three cases of oxaliplatin-related hematological immune reactions. Two patients developed acute immune hemolytic anemia and the third patient had severe thrombocytopenia. One patient had minor undiagnosed hemolysis after the previous chemotherapy cycle and two of our three pati...

Full description

Saved in:
Bibliographic Details
Published in:Tumori 2014-01, Vol.100 (1), p.e17-e19
Main Authors: Garciaz, Sylvain, Oziel-Taieb, Sandrine, Dermeche, Slimane, Ries, Pauline, Vessaud, Julie, Raoul, Jean-Luc
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a series of three cases of oxaliplatin-related hematological immune reactions. Two patients developed acute immune hemolytic anemia and the third patient had severe thrombocytopenia. One patient had minor undiagnosed hemolysis after the previous chemotherapy cycle and two of our three patients had minor allergic signs just before the hemolysis. Fifteen cases of immune hemolytic anemia have been reported in the literature, of which only the first was fatal. One case of hemolytic uremic syndrome has been described. Anemia in cancer patients is not always related to myelosuppression and hemolytic anemia can be a severe side effect of oxaliplatin administration.
ISSN:2038-2529
DOI:10.1700/1430.15831