Determination of trace amounts of ethylene glycol and its analogs in water matrixes by liquid chromatography/tandem mass spectrometry

Contamination of drinking water by ethylene glycol (EG) is a public health concern. EG causes adverse health effects in humans and animals, including cardiopulmonary and acute renal failure. EG and other glycols, such as propylene glycol (PG) are major components in antifreeze liquids, which may be...

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Bibliographic Details
Published in:Journal of AOAC International 2014-01, Vol.97 (1), p.232-237
Main Authors: Tran, Buu N, Okoniewski, Richard, Bucciferro, Anthony, Jansing, Robert, Aldous, Kenneth M
Format: Article
Language:English
Subjects:
Airports
Chemical properties
Chemical research
Chromatography, Liquid - methods
Drinking Water - chemistry
Environment
Environmental Monitoring - methods
Ethylene glycol
Ethylene Glycol - chemistry
Fresh Water - chemistry
Identification and classification
Liquid chromatography
Mass spectrometry
Methods
Micropollutants
Tandem Mass Spectrometry - methods
United States
Water - chemistry
Water Pollutants, Chemical - chemistry
Water pollution
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Summary:Contamination of drinking water by ethylene glycol (EG) is a public health concern. EG causes adverse health effects in humans and animals, including cardiopulmonary and acute renal failure. EG and other glycols, such as propylene glycol (PG) are major components in antifreeze liquids, which may be the main source of contamination of ground water. A sensitive LC/electrospray ionization (ESI)-MS/MS method was developed to measure trace amounts of EG, diethylene glycol, and 1,2- and 1,3-PG in several water sources, including municipal tap, lake, river, and salinated water. In this method, glycols in water samples were derivatized with benzoyl chloride by the Schotten-Baumann reaction, followed by liquid-liquid extraction using pentane as the organic solvent prior to the LC/ESI-MS/MS determination. QC included analysis of a method blank and samples fortified at low and high levels. Analytical data showed excellent linear calibration for all observed glycols, with good precision and accuracy. The method detection limits for the studied glycols ranged from 1.9 to 6.1 ng/mL across the water matrixes tested. This method is suitable to help assess water quality in areas that may be prone to glycol contamination.
ISSN:1060-3271
1944-7922
DOI:10.5740/jaoacint.12-198