MicroRNA-based therapy in pain medicine: Current progress and future prospects

MicroRNAs (miRNAs) are small noncoding RNA molecules of 18–25 nucleotides in length that regulate gene expression involved in fundamental cell processes. The induction and chronification of pain is associated with many expressional changes in pain-related proteins. miRNA has the potential to regulat...

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Bibliographic Details
Published in:Acta anaesthesiologica Taiwanica 2013-12, Vol.51 (4), p.171-176
Main Authors: Tan, Ping-Heng, Pao, Yun-Ying, Cheng, Jen-Kun, Hung, Kuo-Chuan, Liu, Chien-Cheng
Format: Article
Language:English
Subjects:
Animals
Gene Silencing
Humans
Inflammation
Inflammation - genetics
Inflammation - physiopathology
MicroRNAs
MicroRNAs - adverse effects
MicroRNAs - physiology
MicroRNAs - therapeutic use
Neuralgia - genetics
Neuralgia - physiopathology
Pain
Pain - drug therapy
Pain: neuropathic
Visceral Pain
Visceral Pain - genetics
Visceral Pain - physiopathology
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Summary:MicroRNAs (miRNAs) are small noncoding RNA molecules of 18–25 nucleotides in length that regulate gene expression involved in fundamental cell processes. The induction and chronification of pain is associated with many expressional changes in pain-related proteins. miRNA has the potential to regulate gene and protein expression associated with the induction and chronification of pain. Thus, miRNAs might have promise in therapy and as a diagnostic and prognostic biomarker in pain medicine. The application of miRNA has been an emerging field in pain research in recent years. Many studies focusing on the regulation of miRNAs under different tissue and nociceptive stimuli have been performed in recent years. In this review, we intend to introduce the most recent research in the field of miRNA related with pain medicine such as the expression and function of miRNA in different animal pain model, the challenge of application and delivery of miRNA in vivo, the potential toxic effects of miRNA and future problems in clinical application that need to be resolved. This review focuses on the results of miRNA in animal studies and the prospect for future success.
ISSN:1875-4597
1875-452X
DOI:10.1016/j.aat.2013.11.001