Role of SIRT1 and AMPK in mesenchymal stem cells differentiation

• Published in: Ageing research reviews 2014-01, Vol.13, p.55-64
• Main Authors: Chen, Huiqiang, Liu, Xianbao, Chen, Han, Cao, Jiang, Zhang, Ling, Hu, Xinyang, Wang, Jiańan
• Format: Article
• Language: English
• Subjects: Adipocytes - enzymology; Adipogenesis; AMP-Activated Protein Kinases - metabolism; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Applied cell therapy and gene therapy; Biological and medical sciences; Caloric Restriction; Cell Differentiation - drug effects; Cell Lineage; Development. Metamorphosis. Moult. Ageing; Energy Metabolism; Enzyme Activation; Enzyme Activators - pharmacology; Fundamental and applied biological sciences. Psychology; General aspects; Humans; Internal Medicine; Medical sciences; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - enzymology; Neurology; Osteoblasts - enzymology; Osteogenesis; Signal Transduction; Sirtuin 1 - metabolism; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 1568-1637; 1872-9649
• DOI: 10.1016/j.arr.2013.12.002

Highlights • SIRT1 and AMPK might mediate calorie restriction effect on MSCs differentiation. • SIRT1 favors MSCs differentiation toward osteoblast instead of adipocyte lineage. • AMPK favors MSCs differentiation toward osteoblast instead of adipocyte lineage. • Mechanisms of SIRT1 and AMPK action on MSCs differentiation were reviewed. • Synergistic interaction of SIRT1 and AMPK in MSCs differentiation was discussed.