Matrix metalloproteinase enzymes and their naturally derived inhibitors: Novel targets in photocarcinoma therapy

Highlights • Photoaging and activation of matrix metalloproteinase enzymes (MMPs). • The role of matrix metalloproteinase enzymes in degrading the extracellular matrix components (ECM). • Activation and expression of MMPs in different skin disorders. • The targeting of the proteolytic matrix metallo...

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Bibliographic Details
Published in:Ageing research reviews 2014-01, Vol.13, p.65-74
Main Authors: Gupta, Anshita, Kaur, Chanchal Deep, Jangdey, Manmohan, Saraf, Swarnlata
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Dermatology
Development. Metamorphosis. Moult. Ageing
Drug Design
Fundamental and applied biological sciences. Psychology
Humans
Internal Medicine
Matrix Metalloproteinase Inhibitors - therapeutic use
Matrix Metalloproteinases - metabolism
Medical sciences
Molecular Targeted Therapy
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms, Radiation-Induced - drug therapy
Neoplasms, Radiation-Induced - enzymology
Neoplasms, Radiation-Induced - pathology
Neurology
Skin Neoplasms - drug therapy
Skin Neoplasms - enzymology
Skin Neoplasms - pathology
Sunlight - adverse effects
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
Ultraviolet Rays - adverse effects
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Highlights • Photoaging and activation of matrix metalloproteinase enzymes (MMPs). • The role of matrix metalloproteinase enzymes in degrading the extracellular matrix components (ECM). • Activation and expression of MMPs in different skin disorders. • The targeting of the proteolytic matrix metalloproteinase enzymes against photocarcinogenesis and natural bioactives as potent matrix metalloproteinase enzyme inhibitors. • Clinical updates of various MMP inhibitors currently in trial stage with the status of natural bioactives having potential to be a part of future photoprotective chemotherapeutic agent.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2013.12.001