What are the roles of calorie restriction and diet quality in promoting healthy longevity?

Highlights • Healthy nutrition is crucial for promoting health and longevity. • Chronic calorie restriction increases average and maximal lifespan. • Down-regulation of the insulin-IGF signaling pathway extends lifespan in mice. • CR inhibits AKT phosphorylation by 35–50% in human skeletal muscle. •...

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Bibliographic Details
Published in:Ageing research reviews 2014-01, Vol.13, p.38-45
Main Authors: Rizza, Wanda, Veronese, Nicola, Fontana, Luigi
Format: Article
Language:English
Subjects:
Age Factors
Aging - metabolism
Aging - physiology
Animals
Biological and medical sciences
Caloric Restriction
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Development. Metamorphosis. Moult. Ageing
Diet - adverse effects
Energy Metabolism
Epidemiology
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Internal Medicine
Life Expectancy
Life Style
Longevity
Medical sciences
Miscellaneous
Neoplasms - epidemiology
Neoplasms - metabolism
Neoplasms - prevention & control
Neurology
Nutritional Status
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Reduction Behavior
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Highlights • Healthy nutrition is crucial for promoting health and longevity. • Chronic calorie restriction increases average and maximal lifespan. • Down-regulation of the insulin-IGF signaling pathway extends lifespan in mice. • CR inhibits AKT phosphorylation by 35–50% in human skeletal muscle. • Diet quality is as important as calorie intake in modulating health and longevity. • In humans protein intake is an important determinant of serum IGF-1 concentrations.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2013.11.002