High prevalence of vitamin D deficiency among spanish obese children and adolescents

Vitamin D deficiency has been associated with extra-skeletal outcomes such as, insulin resistance, type 2 diabetes, and cardiovascular disease. The aim of this study is to determine the prevalence of vitamin D deficiency among obese children and adolescents in Spain and to analyze the relationship b...

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Bibliographic Details
Published in:Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2014-04, Vol.80 (4), p.229-235
Main Authors: Gutiérrez-Medina, S, Gavela-Pérez, T, Domínguez-Garrido, M N, Blanco-Rodríguez, M, Garcés, C, Rovira, A, Soriano-Guillén, L
Format: Article
Language:Spanish
Subjects:
Adolescent
Biomarkers - blood
Child
Cross-Sectional Studies
Female
Humans
Male
Obesity - blood
Obesity - complications
Prevalence
Spain
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
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Summary:Vitamin D deficiency has been associated with extra-skeletal outcomes such as, insulin resistance, type 2 diabetes, and cardiovascular disease. The aim of this study is to determine the prevalence of vitamin D deficiency among obese children and adolescents in Spain and to analyze the relationship between 25-OH-vitamin D (25-OH-D) levels and markers of abnormal glucose metabolism. A cross-sectional study was conducted in which the clinical and biochemical data were recorded for 120 obese and 50 non-overweight children in Pediatric Clinics from January 2011 to January 2013. The mean 25-OH-D levels among obese children was 19.5 ng/ml and among non-overweight children was 31.6 ng/ml. 58,3% of obese subjects, and 10% of non-overweight subjects had vitamin D deficiency. Serum 25-OH-D levels were lower in winter. Higher HOMA-SDS (3.8 versus 2.4), and triglycerides (97 versus 81 mg/dl) were found in vitamin D deficient obese children compared to obese children without vitamin D deficiency. A negative correlation was found between 25-OH-D levels and HOMA in absolute values (r=-0.2; P=.04) that was not maintained when HOMA-SDS was analyzed. There is a high prevalence of vitamin D deficiency among obese children with a multifactorial etiology. A lower 25-OH-D level could be a risk factor for developing insulin resistance and type 2 diabetes in obese population.
ISSN:1695-9531
DOI:10.1016/j.anpedi.2013.06.032