Glucose repression of anaerobic genes of Escherichia coli is independent of cyclic AMP

Several anaerobically regulated gene fusions were examined for the effects of catabolite repression. Glucose repressed the expression of most of the genes represented in our collection of anaerobically induced fusions. However, addition of cyclic AMP did not reverse the effects of glucose. Furthermo...

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Bibliographic Details
Published in:FEMS microbiology letters 1988-12, Vol.56 (2), p.231-235
Main Authors: Reams, Stephen G., Clark, David P.
Format: Article
Language:English
Subjects:
Anaerobic
Bacteriology
Beta‐galactosidase
Biological and medical sciences
Catabolite repression
Escherichia coli
Fundamental and applied biological sciences. Psychology
Gene fusion
Genetics
Microbiology
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Summary:Several anaerobically regulated gene fusions were examined for the effects of catabolite repression. Glucose repressed the expression of most of the genes represented in our collection of anaerobically induced fusions. However, addition of cyclic AMP did not reverse the effects of glucose. Furthermore, introduction of cya and crp mutations into selected anaerobically induced fusion strains did not reduce anaerobic gene expression as expected from the known mechanism of aerobic catabolite repression. In fact, in different fusion strains, cya or crp mutations caused from 2 to 20‐fold increases in gene expression. Although glucose repression occurs anaerobically its mechanism would appear to be quite different from that under aerobic conditions.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1988.tb03183.x