Synthesis, structures, and Helicobacter Pylori urease inhibition of hydroxamate-coordinated oxovanadium complexes with benzohydrazone ligands

A new acetohydroxamate-coordinated oxovanadium(V) complex, [VOL(AE)] ( 1 ), and a new benzohydroxamate-coordinated oxovanadium(V) complex, [VOL(BE)] ( 2 ), where L is the dianionic form of N ′-(2-hydroxy-5-methylbenzylidene)-2-methoxybenzohydrazide, have been synthesized and characterized by physico...

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Bibliographic Details
Published in:Transition metal chemistry (Weinheim) 2014-04, Vol.39 (3), p.291-297
Main Authors: Cheng, Xiao-Shan, Zhang, Ji-Cai, You, Zhong-Lu, Wang, Xue, Li, Hai-Hua
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Helicobacter pylori
Inorganic Chemistry
Organometallic Chemistry
Physical Chemistry
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Summary:A new acetohydroxamate-coordinated oxovanadium(V) complex, [VOL(AE)] ( 1 ), and a new benzohydroxamate-coordinated oxovanadium(V) complex, [VOL(BE)] ( 2 ), where L is the dianionic form of N ′-(2-hydroxy-5-methylbenzylidene)-2-methoxybenzohydrazide, have been synthesized and characterized by physicochemical methods and single-crystal X-ray diffraction. The V atom in each complex adopts octahedral coordination. Thermal stabilities and urease inhibitory activities of the complexes were studied. The percent inhibition of complexes 1 and 2 at the concentration of 100 μmol L −1 on Helicobacter pylori urease is 81.2 and 46.7 %, respectively. Complex 1 has an IC 50 value of 27.0 μmol L −1 . A molecular docking study of the complexes with the H. pylori urease was performed.
ISSN:0340-4285
1572-901X
DOI:10.1007/s11243-014-9802-4