Biodistribution and lymph node retention of polysaccharide-based immunostimulating nanocapsules

Highlights • We studied the biodistribution of PG-nanocapsules using scintigraphic imaging. • We report an efficient method for radiolabeling PG nanocapsules using indium-111. • PG-nanocapsules formed a depot at the injection site compared with In-111 control. • PG-nanocapsules were retained in drai...

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Bibliographic Details
Published in:Vaccine 2014-03, Vol.32 (15), p.1685-1692
Main Authors: Vicente, Sara, Goins, Beth A, Sanchez, Alejandro, Alonso, María J, Phillips, William T
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacokinetics
Allergy and Immunology
Animals
Applied microbiology
Aqueous solutions
Biodistribution
Biological and medical sciences
Chitosan
Efficiency
Fundamental and applied biological sciences. Psychology
Glucosamine - pharmacokinetics
Imaging
Immune system
Injection
Labeling
Lymph node
Lymph nodes
Lymph Nodes - diagnostic imaging
Lymphoscintigraphy
Male
Microbiology
Migration
Nanocapsules
Nanocarrier
Nanoparticles
Nanovaccine
Polysaccharides - pharmacokinetics
Rabbits
Retention
Studies
Tissue Distribution
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Zeta potential
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Summary:Highlights • We studied the biodistribution of PG-nanocapsules using scintigraphic imaging. • We report an efficient method for radiolabeling PG nanocapsules using indium-111. • PG-nanocapsules formed a depot at the injection site compared with In-111 control. • PG-nanocapsules were retained in draining lymph nodes for a prolonged time. • Lymphatic distribution of PG-nanocapsules may describe reported adjuvant effects.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.01.059