Association of polymorphisms in interleukin-18 and interleukin-28B genes with outcomes of hepatitis B virus infections: a meta-analysis

• Published in: Tumor biology 2014-02, Vol.35 (2), p.1129-1137
• Main Authors: Xia, Pu, Zhou, Mo, Dong, Dao Song, Xing, Ya-Nan, Bai, Yang
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - virology; Clinical outcomes; Genes; Genetic Association Studies; Hepatitis; Hepatitis B - complications; Hepatitis B - virology; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - pathogenicity; Humans; Interferons; Interleukin-18 - genetics; Interleukins - genetics; Liver Cirrhosis - complications; Liver Cirrhosis - pathology; Liver Cirrhosis - virology; Liver Neoplasms - complications; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver Neoplasms - virology; Meta-analysis; Polymorphism; Polymorphism, Single Nucleotide; Research Article
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-013-1151-y

Several polymorphisms in the interleukin-18 ( IL-18 ) and nterleukin-28B ( IL-28B ) genes have been reported to influence hepatitis B virus (HBV) infection. However, the published findings have been conflicting. We conducted meta-analyses of randomized, controlled trials to address the association of IL-18 or IL-28B polymorphisms and the outcomes of HBV infection. Weipu, Wanfang, CNKI, MEDLINE, PubMed, EMBASE, and Cochrane Library databases were employed to search for citations using the MeSH terms as “interleukin-18”/“interleukin-28B” AND “HBV” AND “gene” AND “polymorphism” without any restriction in language and publication year. Meta-analysis was conducted by RevMan 5.0 software. The results showed that the IL28B rs8099917 AA genotype (AA vs AC + CC: odds ratio (OR) = 0.63, 95 % confidence interval (CI) = 0.46–0.87) was associated with a decreased risk of hepatocellular carcinoma (HCC). Carriage of IL28B rs12979860 CC genotype was associated with an increased risk for developing liver cirrhosis among patients with HBV infection (CC vs CT + TT: OR = 1.39, 95 % CI = 1.04–1.85). Further well-designed large studies are warranted to confirm the mechanisms by which these are involved in these outcomes of HBV infection.