Antimicrobial susceptibility profile of Acinetobacter species isolated from blood cultures in two Japanese university hospitals

ABSTRACT Carbapenem‐resistant Acinetobacter baumannii has rapidly spread worldwide. This study investigated antibiotic susceptibility and genotypic resistance of 123 consecutive blood culture isolates of Acinetobacter species collected between 2003 and 2011 in two Japanese hospitals. The isolates we...

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Bibliographic Details
Published in:Microbiology and immunology 2014-02, Vol.58 (2), p.142-146
Main Authors: Kishii, Kozue, Kikuchi, Ken, Yoshida, Atsushi, Okuzumi, Katsuko, Uetera, Yushi, Yasuhara, Hiroshi, Moriya, Kyoji
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter - classification
Acinetobacter - drug effects
Acinetobacter - genetics
Acinetobacter - isolation & purification
Acinetobacter baumannii
Acinetobacter Infections - diagnosis
Acinetobacter Infections - microbiology
Anti-Infective Agents - pharmacology
blaOXA23
Blood
Drug Resistance, Bacterial - genetics
Genes, Bacterial
Hospitals, University
Humans
IMP-1
Japan
Microbial Sensitivity Tests
non-Acinetobacter baumannii complex
quinolone resistance-determining region
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Summary:ABSTRACT Carbapenem‐resistant Acinetobacter baumannii has rapidly spread worldwide. This study investigated antibiotic susceptibility and genotypic resistance of 123 consecutive blood culture isolates of Acinetobacter species collected between 2003 and 2011 in two Japanese hospitals. The isolates were assigned to 13 species. Carbapenem resistance was detected in four isolates. Only one A. baumannii isolate had blaOXA‐23 together with ISAba1; the remaining three isolates had IMP‐1 metallo‐β‐lactamase. Quinolone resistance was detected in five isolates that had point mutations in the quinolone resistance‐determining region. The predominance of various non‐A. baumannii species and low prevalence of carbapenem resistance among blood culture isolates of Acinetobacter species in two Japanese hospitals were confirmed.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12117