Protective effect of ascorbic acid against ethanol-induced reproductive toxicity in male guinea pigs

The present study was undertaken to elucidate the effect of ascorbic acid on alcohol-induced reproductive toxicity and also to compare it with that of abstention. A total of thirty-six male guinea pigs were divided into two groups and were maintained for 90 d as control and ethanol-treated groups (4...

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Bibliographic Details
Published in:British journal of nutrition 2013-08, Vol.110 (4), p.689-698
Main Authors: Harikrishnan, R., Abhilash, P. A., Syam Das, S., Prathibha, P., Rejitha, S., John, Febi, Kavitha, S., Indira, M.
Format: Article
Language:English
Subjects:
Acids
Addictive behaviors
Adult and adolescent clinical studies
Alcoholism
Alcoholism and acute alcohol poisoning
Animal reproduction
Animals
Antioxidants - metabolism
Ascorbic Acid - pharmacology
Biological and medical sciences
Body Weight
Cell Survival
Chromatography, High Pressure Liquid - methods
Dehydrogenase
Dietary Supplements
Dose-Response Relationship, Drug
Ethanol
Ethanol - adverse effects
Feeding. Feeding behavior
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Gonadotropins - metabolism
Guinea Pigs
Luteinizing Hormone - blood
Male
Medical sciences
Nutritional Toxicology
Oxidative Stress
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reproduction - drug effects
Rodents
Semen - metabolism
Steroids - metabolism
Testosterone - blood
Toxicity
Toxicology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The present study was undertaken to elucidate the effect of ascorbic acid on alcohol-induced reproductive toxicity and also to compare it with that of abstention. A total of thirty-six male guinea pigs were divided into two groups and were maintained for 90 d as control and ethanol-treated groups (4 g/kg body weight (b.wt.)). After 90 d, ethanol administration was stopped and animals in the control group were divided into two groups and then maintained for 30 d as the control and control+ascorbic acid groups and those in the ethanol-treated group as ethanol abstention and ethanol+ascorbic acid (25 mg/100 g b. wt.) groups. Animals treated with ethanol showed a significant decline in sperm quality (P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114512005739