Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine

In order to treat dental caries of damaged dentine, triclosan-loaded carboxyl-terminated poly(amido amine) dendrimer (PAMAM-COOH) is prepared and characterized. While being incubated in artificial saliva, triclosan-loaded PAMAM-COOH formulation can induce in situ remineralization of hydroxyapatite (...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-03, Vol.115, p.237-243
Main Authors: Zhou, Yan, Yang, Jiaojiao, Lin, Zaifu, Li, Jiyao, Liang, Kunneng, Yuan, He, Li, Sheyu, Li, Jianshu
Format: Article
Language:English
Subjects:
Animals
Cell Death - drug effects
Cell Survival - drug effects
Dendrimers - chemistry
Dendrimers - pharmacology
Dentin - drug effects
Dentin - metabolism
Dentin - ultrastructure
Durapatite - chemistry
Humans
Magnetic Resonance Spectroscopy
Mice
Polyamines - chemistry
Polyamines - pharmacology
Saliva - chemistry
Solutions
Spectroscopy, Fourier Transform Infrared
Tooth Remineralization
Triclosan - chemistry
Triclosan - pharmacology
X-Ray Diffraction
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Summary:In order to treat dental caries of damaged dentine, triclosan-loaded carboxyl-terminated poly(amido amine) dendrimer (PAMAM-COOH) is prepared and characterized. While being incubated in artificial saliva, triclosan-loaded PAMAM-COOH formulation can induce in situ remineralization of hydroxyapatite (HA) on etched dentine, and the regenerated HA has a similar crystal structure with natural dentine. It can also release the encapsulated triclosan for a long period. The interesting drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree, which are ideal to obtain multifunctional properties of long-term release of anti-bacterial drug for local treatment during the remineralization process. The triclosan-loaded G4-COOH provides a general strategy to cure dental caries and repair damaged dentine at the same time, which forms a potential restorative material for dental repair.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2013.11.045