Tight junction dynamics: the role of junctional adhesion molecules (JAMs)

Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20 years of research in this field has shown that several members of the family play an important role in the regulation of cell...

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Bibliographic Details
Published in:Cell and tissue research 2014-03, Vol.355 (3), p.701-715
Main Authors: Garrido-Urbani, S, Bradfield, P. F, Imhof, B. A
Format: Article
Language:English
Subjects:
adhesion
Animals
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Cell adhesion & migration
cell movement
Cell Movement - physiology
cell polarity
Endothelium
Human Genetics
Humans
Junctional Adhesion Molecules - physiology
Leukocytes
Leukocytes - physiology
Molecular Medicine
Permeability
Proteomics
Review
tight junctions
Tight Junctions - physiology
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Summary:Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20 years of research in this field has shown that several members of the family play an important role in the regulation of cell polarity, endothelium permeability and leukocytes migration. They mediate these pleiotropic functions through a multitude of homophilic and heterophilic interactions with intrafamily and extrafamily partners. In this article, we review the current status of the JAM family and highlight their functional role in tight junction dynamics and leukocyte transmigration.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-014-1820-1