Factors influencing patient satisfaction with antimuscarinic treatment of overactive bladder syndrome: Results of a real-life clinical study

• Published in: International journal of urology 2014-04, Vol.21 (4), p.389-394
• Main Authors: Akino, Hironobu, Namiki, Mikio, Suzuki, Koji, Fuse, Hideki, Kitagawa, Yasuhide, Miyazawa, Katsuhito, Fujiuchi, Yasuyoshi, Yokoyama, Osamu
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; antimuscarinic agent; Benzhydryl Compounds - administration & dosage; Benzhydryl Compounds - adverse effects; Benzilates - administration & dosage; Benzilates - adverse effects; constipation; Cresols - administration & dosage; Cresols - adverse effects; Cross-Sectional Studies; Female; Humans; imidafenacin; Imidazoles - administration & dosage; Imidazoles - adverse effects; Japan; Male; Mandelic Acids - administration & dosage; Mandelic Acids - adverse effects; Middle Aged; Muscarinic Antagonists - administration & dosage; Muscarinic Antagonists - adverse effects; overactive bladder; Patient Satisfaction; Phenylpropanolamine - administration & dosage; Phenylpropanolamine - adverse effects; Quinuclidines - administration & dosage; Quinuclidines - adverse effects; satisfaction; Solifenacin Succinate; Tetrahydroisoquinolines - administration & dosage; Tetrahydroisoquinolines - adverse effects; Tolterodine Tartrate; Treatment Outcome; Urinary Bladder, Overactive - drug therapy
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/iju.12298

Objectives To investigate patient satisfaction with antimuscarinic treatment of overactive bladder syndrome, and to identify factors having a significant influence on satisfaction. Methods A cross‐sectional questionnaire survey was carried out to assess treatment satisfaction among male and female patients with overactive bladder (age ≥20 years) in the Hokuriku district of Japan. The overactive bladder symptom scores, treatment efficacies, adverse events (dry mouth and constipation), and patient satisfaction scores were investigated and compared among patients using different antimuscarinic therapeutics. Results In total, 977 survey respondents (52.6% men; mean age 73.6 years) received antimuscarinic treatment. The mean overactive bladder symptom score of these patients was 6.17; in addition, 32.3% patients were satisfied with their treatment, but 33.1% were dissatisfied. Factors having a significant influence on treatment satisfaction were sex (men were less satisfied), efficacy, adverse events and the overactive bladder symptom score. Constipation negatively influenced patient satisfaction to a greater extent than did dry mouth. Patient satisfaction varied according to the drug used. Constipation was less severe with the immediate‐release‐type agents (imidafenacin and oxybutynin) than with the extended‐release‐type (propiverine, solifenacin or tolterodine). Conclusions Just one‐third of Japanese Hokuriku patients with overactive bladder seem to be satisfied with their antimuscarinic treatment. Patient satisfaction is impaired by poor efficacy and the presence of adverse events; furthermore, constipation should be recognized as an adverse event that negatively influences patient satisfaction to a greater extent than dry mouth. Patient satisfaction differs according to the antimuscarinic agent used, with higher patient satisfaction being associated with less severe constipation.