Biological Studies of Turmeric Oil, Part 3: Anti-Inflammatory and Analgesic Properties of Turmeric Oil and Fish Oil in Comparison with Aspirin

• Published in: Natural product communications 2014-02, Vol.9 (2), p.225-228
• Main Authors: Jacob, James N., Badyal, Dinesh K.
• Format: Article
• Language: English
• Subjects: Analgesics - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; Aspirin - pharmacology; Curcuma; Female; Fish Oils - pharmacology; Male; Plant Oils - pharmacology; Rats
• ISSN: 1934-578X; 1555-9475
• DOI: 10.1177/1934578X1400900224

Turmeric and fish oil have been gaining interest as food supplements because of their beneficial properties. Turmeric oil contains sesquiterpenes and fish oil has eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possessing anti-inflammatory activity. The present study is to evaluate and compare the anti-inflammatory and analgesic properties of these two natural food products with aspirin as a standard. The percent inhibition as a measure of paw edema for turmeric oil and fish oil at 100 mg/kg was 76% and 31%, respectively, while the percent inhibition by the combination of the two at 100 mg/kg was 62%, which was the same as that of aspirin at the same dose. The inhibitory activity of fish oil at 50 mg/kg was 86% and with an increase in dose the activity decreased. The analgesic activity measured by the tail flick method showed optimum activities for turmeric oil and fish oil at 60 and 90 minutes, respectively, whereas the combination of the two decreased the analgesic activity. Thus the two common food ingredients, oils from turmeric and fish, have desirable biochemical properties to develop further their use as food and medicine.