A nomogram for predicting individual survival of patients with gastric cancer who underwent radical surgery with extended lymph node dissection

Background We developed and validated a nomogram for use at a high-volume center where radical surgery with extended lymph node dissection is the standard treatment for gastric cancer. Methods Overall, 1,614 patients were randomly divided into the test set ( n  = 805) and validation set ( n  = 809)....

Full description

Saved in:
Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2014-04, Vol.17 (2), p.287-293
Main Authors: Song, Kyo Young, Park, Yong Gyu, Jeon, Hae Myung, Park, Cho Hyun
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Cancer Research
Female
Follow-Up Studies
Gastrectomy - mortality
Gastric cancer
Gastroenterology
Humans
Lymph Node Excision - mortality
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Nomograms
Oncology
Original Article
Prognosis
Prospective Studies
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgical Oncology
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background We developed and validated a nomogram for use at a high-volume center where radical surgery with extended lymph node dissection is the standard treatment for gastric cancer. Methods Overall, 1,614 patients were randomly divided into the test set ( n  = 805) and validation set ( n  = 809). The scoring system was calculated using a Cox proportional hazard regression model with the survival of gastric cancer as the predicted endpoint. The concordance index (c-index) was used as an accuracy measure, with bootstrapping to correct for optimistic bias. Calibration plots were constructed. Results Based on a Cox model, we developed a nomogram that predicts the probability of 3- and 5-year survival from the time of surgery. The bootstrap-corrected c-indices were 0.87 and 0.84 in the test and validation sets, respectively. Survival was well predicted in both sets. The predictions of our nomogram discriminated better than the AJCC staging system (test set: c-index, 0.87 vs. 0.77; P  
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-013-0270-x