Predictive value of diffusion-weighted magnetic resonance imaging during chemoradiotherapy for uterine cervical cancer

• Published in: The journal of obstetrics and gynaecology research 2014-04, Vol.40 (4), p.1098-1104
• Main Authors: Makino, Hiroshi, Kato, Hiroki, Furui, Tatsuro, Morishige, Ken-ichirou, Kanematsu, Masayuki
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Adult; Aged; Aged, 80 and over; Biomarkers; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Cervix Uteri - drug effects; Cervix Uteri - pathology; Cervix Uteri - radiation effects; Chemoradiotherapy; Cohort Studies; Diffusion Magnetic Resonance Imaging; diffusion-weighted imaging; Female; Follow-Up Studies; Humans; magnetic resonance imaging; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; treatment response; uterine cervical cancer; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - therapy
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.12276

Aim The purpose of this study was to evaluate the efficacy of diffusion‐weighted (DW) magnetic resonance (MR) imaging to predict the tumor response to chemoradiotherapy (CRT) of uterine cervical cancer. Methods Twenty‐five consecutive patients with pathologically confirmed uterine cervical cancer underwent 1.5‐T MR imaging including DW imaging before and during CRT. MR images were reviewed for the size and apparent diffusion coefficient (ADC). Pathological evaluation of the therapeutic effect was performed 3 months after finishing CRT, and we divided the subjects into two groups: complete remission (CR) (n = 16) and residual tumor (n = 9). Results ADC was lower before CRT than during CRT (0.89 ± 0.12 and 1.25 ± 0.22 × 10−3 mm2/s, respectively) (P