Clinicopathological features of narrow-band imaging endoscopy and immunohistochemistry in ultraminute esophageal squamous neoplasms

Summary To reveal clinicopathological features of narrow‐band imaging (NBI) endoscopy and immunohistochemistry in ultraminute esophageal squamous neoplasms. If a lesion diameter was smaller or same compared with a width of closed biopsy forceps, a lesion was defined to be an ultraminute lesion. Twen...

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Bibliographic Details
Published in:Diseases of the esophagus 2014-04, Vol.27 (3), p.267-275
Main Authors: Goda, K., Dobashi, A., Yoshimura, N., Chiba, M., Fukuda, A., Nakao, Y., Ohya, T. R., Sasaki, Y., Kato, M., Aihara, H., Sumiyama, K., Toyoizumi, H., Kato, T., Tajiri, H., Ikegami, M.
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - analysis
Carcinoma in Situ - chemistry
Carcinoma in Situ - pathology
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - pathology
Coloring Agents
Esophageal Neoplasms - chemistry
Esophageal Neoplasms - pathology
esophageal squamous neoplasm
Esophagoscopy
Female
Humans
Immunohistochemistry
intraepithelial neoplasia
Iodides
Ki-67 Antigen - analysis
Male
Middle Aged
Narrow Band Imaging
Retrospective Studies
Tumor Suppressor Protein p53 - analysis
ultraminute
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Summary:Summary To reveal clinicopathological features of narrow‐band imaging (NBI) endoscopy and immunohistochemistry in ultraminute esophageal squamous neoplasms. If a lesion diameter was smaller or same compared with a width of closed biopsy forceps, a lesion was defined to be an ultraminute lesion. Twenty‐five consecutive patients with 33 ultraminute esophageal lesions that were removed by endoscopic mucosal resection were included in the present study. We conducted two questionnaire surveys of six endoscopists by their retrospective review of endoscopic still images. The six endoscopists evaluated the endoscopic findings of the ultraminute lesions on still images taken by conventional white‐light imaging endoscopy and non‐magnified NBI endoscopy in the first questionnaire, and taken by magnified NBI endoscopy in the second questionnaire. An experienced pathologist who was unaware of any endoscopic findings made histological diagnosis and evaluated immunoexpression of p53 and Ki67. The 33 ultraminute lesions were all determined to be either 11 high‐grade intraepithelial neoplasias (HGIENs) or 22 low‐grade intraepithelial neoplasias (LGIENs). The tumor diameters were histologically confirmed to be
ISSN:1120-8694
1442-2050
DOI:10.1111/dote.12090