A dose-response analysis of cadmium in the general environment with special reference to total cadmium intake limit

An epidemiological study on the dose-response relationship of cadmium was performed on 1850 Cd-exposed and 294 nonexposed inhabitants of the Kakehashi River basin in Ishikawa Prefecture. β 2-microglobulinuria was used as an index of the effect of cadmium on health and the average cadmium concentrati...

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Bibliographic Details
Published in:Environmental research 1989-02, Vol.48 (1), p.7-16
Main Authors: Nogawa, Koji, Honda, Ryumon, Kido, Teruhiko, Tsuritani, Ikiko, Yamada, Yuichi, Ishizaki, Masao, Yamaya, Haruki
Format: Article
Language:English
Subjects:
Aged
beta 2-Microglobulin - urine
Biological and medical sciences
Cadmium - toxicity
Chemical and industrial products toxicology. Toxic occupational diseases
Dose-Response Relationship, Drug
Female
Humans
Kidney - drug effects
Male
Maximum Allowable Concentration
Medical sciences
Metals and various inorganic compounds
Middle Aged
Toxicology
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Summary:An epidemiological study on the dose-response relationship of cadmium was performed on 1850 Cd-exposed and 294 nonexposed inhabitants of the Kakehashi River basin in Ishikawa Prefecture. β 2-microglobulinuria was used as an index of the effect of cadmium on health and the average cadmium concentration in locally produced rice was employed as an indicator of cadmium exposure. Cadmium exposure was found to affect health in a dose-related manner when the subjects were classified according to the average cadmium concentration in their village rice and their length of residence in the polluted area. Based on the available data, the total cadmium intake that produced an adverse effect on health was calculated as approximately 2000 mg for both men and women.
ISSN:0013-9351
1096-0953
DOI:10.1016/S0013-9351(89)80080-5