Retinal Dopamine and Form-Deprivation Myopia

Investigation of retinal neurochemistry in a well-defined chick model of form-deprivation myopia indicated that dopamine and its metabolite 3,4-dihydroxyphenylacetic acid are reduced in myopic as compared to control eyes. The reduction in retinal dopamine is evident only during light adaptation and...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1989-01, Vol.86 (2), p.704-706
Main Authors: Stone, Richard A., Lin, Ton, Laties, Alan M., Iuvone, P. Michael
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chickens
Dopamine - analysis
Dopamine - metabolism
Dopamine receptors
Dosage
Eyes
Goggles
Histocytochemistry
Immunohistochemistry
Light adaptation
Medical sciences
Metabolism
Metabolites
Myopia
Myopia - metabolism
Ophthalmology
Retina
Retina - analysis
Retina - metabolism
Vision disorders
Visual deprivation
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Summary:Investigation of retinal neurochemistry in a well-defined chick model of form-deprivation myopia indicated that dopamine and its metabolite 3,4-dihydroxyphenylacetic acid are reduced in myopic as compared to control eyes. The reduction in retinal dopamine is evident only during light adaptation and is accompanied by a decreased rate of dopamine biosynthesis. To test whether the alteration in dopamine metabolism is related to eye growth, agents known to interact with dopamine receptors were administered locally to deprived eyes. Remarkably, the expected growth in the axial dimension was reduced, while that in the equatorial dimension was not. Therefore retinal dopamine may participate in the pathway linking visual experience and the postnatal regulation of the eye's growth in the axial dimension. The mechanism for control of chick eye growth in the equatorial dimension remains unknown.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.86.2.704