Emergence of extended-spectrum [Beta]-lactamase-producing Escherichia coli in catheter-associated urinary tract infection in neurogenic bladder patients

Catheter-associated urinary tract infection (CAUTI) is a common clinic problem. The purpose of this study was to investigate recent trends in CAUTI in neurogenic bladder patients focusing on extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. Isolates from the urine of neurogenic bladde...

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Bibliographic Details
Published in:American journal of infection control 2014-03, Vol.42 (3), p.E29-e31
Main Authors: Takaba, Kei, Shigemura, Katsumi, Osawa, Kayo, Nomi, Masashi, Fujisawa, Masato, Arakawa, Soichi
Format: Article
Language:English
Subjects:
Bladder
Catheters
E coli
Polymerase chain reaction
Urinary tract diseases
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Summary:Catheter-associated urinary tract infection (CAUTI) is a common clinic problem. The purpose of this study was to investigate recent trends in CAUTI in neurogenic bladder patients focusing on extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. Isolates from the urine of neurogenic bladder patients with UTI were investigated. Nine strains of ESBL-producing E coli were assayed by molecular strain typing using the Diversilab system for repetitive-sequence-based polymerase chain reaction (rep-PCR). E coli accounted for most of the bacteria (74.1% to 81.0%) that produced ESBLs. Rep-PCR data showed that 7 out of 9 ESBL-producing E coli belonged to the same typing group with high similarity (more than 97% similarity) and that this distribution corresponded with antibiotic resistance patterns. ESBL producing E coli strains isolated from CAUTI patients could be discriminated by rep-PCR typing using the Diversilab system in consistent with antibiotic resistance patterns.
ISSN:0196-6553
1527-3296