Pharmacokinetics and ex vivo pharmacodynamics of cefquinome in porcine serum and tissue cage fluids

• Published in: The veterinary journal (1997) 2014-03, Vol.199 (3), p.399-405
• Main Authors: Zhang, B.X., Lu, X.X., Gu, X.Y., Li, X.H., Gu, M.X., Zhang, N., Shen, X.G., Ding, H.Z.
• Format: Article
• Language: English
• Subjects: Administration, Intravenous - veterinary; Animals; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Cefquinome; Cephalosporins - blood; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Chromatography, High Pressure Liquid - veterinary; Diffusion Chambers, Culture - veterinary; Escherichia coli; Escherichia coli - drug effects; Ex vivo; Female; Injections, Intramuscular - veterinary; Male; Microbial Sensitivity Tests - veterinary; Piglets; Swine - metabolism; Tissue cage fluids
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2013.12.015

A tissue cage (TC) model was used to evaluate the pharmacokinetics and ex vivo pharmacodynamics of cefquinome after intravenous (IV) and intramuscular (IM) administration to piglets at 2mg/kg bodyweight. The mean values of area under the concentration–time curve (AUC) were 21.28 (IV) and 21.37 (IM)μgh/mL for serum, and 17.40 (IV) and 16.57 (IM)μgh/mL for TC fluid (TCF), respectively. Values of maximum concentration (Cmax) were 6.15μg/mL (serum) and 1.15μg/mL (TCF) after IM administration. The elimination half-lives (t1/2β) in TCF (10.63h IV and 11.81h IM) were significantly higher than those in serum (2.33h IV and 2.30h IM) (P