Spinal Cord Stimulation for Heart Failure: Preclinical Studies to Determine Optimal Stimulation Parameters for Clinical Efficacy

Spinal cord stimulation with implantable devices has been used worldwide for decades to treat regional pain conditions and cardiac angina refractory to conventional therapies. Preclinical studies with spinal cord stimulation in experimental animal models of heart disease have described interesting e...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular translational research 2014-04, Vol.7 (3), p.321-329
Main Authors: Lopshire, John C., Zipes, Douglas P.
Format: Article
Language:English
Subjects:
Animals
Arrhythmias, Cardiac - physiopathology
Autonomic Nervous System - physiopathology
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Disease Models, Animal
Heart Failure - physiopathology
Heart Failure - therapy
Human Genetics
Humans
Medicine
Medicine & Public Health
Spinal Cord Stimulation - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spinal cord stimulation with implantable devices has been used worldwide for decades to treat regional pain conditions and cardiac angina refractory to conventional therapies. Preclinical studies with spinal cord stimulation in experimental animal models of heart disease have described interesting effects on cardiac and autonomic nervous system physiology. In canine and porcine animals with failing hearts, spinal cord stimulation reverses left ventricular dilation and improves cardiac function, while suppressing the prevalence of cardiac arrhythmias. In this paper, we present further canine studies that determined the optimal site and intensity of spinal cord stimulation that produced the most robust and beneficial clinical response in heart failure animals. We then explore and discuss the clinically relevant aspects and potential impediments that may be encountered in translating spinal cord stimulation to human patients with advanced cardiac disease.
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-014-9547-7