The progress and future of enhancing antiviral capacity by transgenic technology in the silkworm Bombyx mori

Bombyx mori is a common lepidopteran model and an important economic insect for silk production. B. mori nucleopolyhedrovirus (BmNPV) is a typical pathogenic baculovirus that causes serious economic losses in sericulture. B. mori and BmNPV are a model of insect host and pathogen interaction includin...

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Bibliographic Details
Published in:Insect biochemistry and molecular biology 2014-05, Vol.48, p.1-7
Main Authors: Jiang, Liang, Xia, Qingyou
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Antivirus
Bombyx - genetics
Bombyx - immunology
Bombyx - virology
Commercial
DNA, Viral - genetics
Gastrointestinal Tract - virology
Larva - virology
Nucleopolyhedrovirus - genetics
RNA Interference
Safety
Silkworm
Transgenic
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Summary:Bombyx mori is a common lepidopteran model and an important economic insect for silk production. B. mori nucleopolyhedrovirus (BmNPV) is a typical pathogenic baculovirus that causes serious economic losses in sericulture. B. mori and BmNPV are a model of insect host and pathogen interaction including invasion of the host by the pathogen, host response, and enhancement of host resistance. The antiviral capacity of silkworms can be improved by transgenic technology such as overexpression of an endogenous or exogenous antiviral gene, RNA interference of the BmNPV gene, or regulation of the immune pathway to inhibit BmNPV at different stages of infection. Antiviral capacity could be further increased by combining different methods. We discuss the future of an antiviral strategy in silkworm, including possible improvement of anti-BmNPV, the feasibility of constructing transgenic silkworms with resistance to multiple viruses, and the safety of transgenic silkworms. The silkworm model could provide a reference for disease control in other organisms. •Review the antiviral strategies based on the infection process of BmNPV in silkworm.•Look forward of the future of antiviral strategies in transgenic silkworms.•Discuss the problems in commercial application of a transgenic silkworm.
ISSN:0965-1748
1879-0240
DOI:10.1016/j.ibmb.2014.02.003