Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients

Tumor recurrence and metastasis are pressing issues of patients with colorectal cancer who receive surgery. Matrilysin-2 (MMP-26) has been proved to play an important role during invasion and metastasis of some human solid tumor. We aimed to investigate the clinical significance and prognostic value...

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Bibliographic Details
Published in:Tumor biology 2014-04, Vol.35 (4), p.3569-3574
Main Authors: Hu, Qinglin, Yan, Chuanjing, Xu, Chengfei, Yan, Hai, Qing, Lian, Pu, Yanjun, He, Zeyou, Li, Xiaojun
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal cancer
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Humans
Immunohistochemistry
Male
Matrix Metalloproteinases - physiology
Matrix Metalloproteinases, Secreted - analysis
Matrix Metalloproteinases, Secreted - physiology
Medical prognosis
Middle Aged
Neoplasm Staging
Protein expression
Research Article
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Summary:Tumor recurrence and metastasis are pressing issues of patients with colorectal cancer who receive surgery. Matrilysin-2 (MMP-26) has been proved to play an important role during invasion and metastasis of some human solid tumor. We aimed to investigate the clinical significance and prognostic value of matrilysin-2 in human colorectal cancer. Colorectal cancer and adjacent normal samples from 201 patients were collected. Matrilysin-2 expression level was investigated by immunohistochemistry assay, and its association with overall survival of patients was analyzed by statistical analysis. Results showed that matrilysin-2 expression level significantly elevated in colorectal cancer compared with adjacent normal specimens. Matrilysin-2 expression was also found to be associated with cancer invasion, lymph node metastasis, distant metastasis, and TNM stage. In addition, survival analysis showed that elevated matrilysin-2 expression was associated with poor overall survival of patients. Cox's proportional hazards model indicated that matrilysin-2 was an independent prognostic marker for patients with colorectal cancer. The present study found that the expression of matrilysin-2 increased in colorectal cancer and was associated with tumor progression. It also provided the first evidence that matrilysin-2 expression was an independent prognostic factor for patients with colorectal cancer, which might be a high specific biomarker for colorectal cancer.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-013-1471-y