Arsenic and type 2 diabetes: commentary on association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis by Wang et al

Approximately 75% of absorbed iAs is excreted in urine as monomethylarsonic acid and dimethylarsinic acid. 36 Using total urinary arsenic is a major limitation because arsenobetaine is excreted after ingestion of various seafoods and should not be included in the iAs exposure assessment in urine. 36...

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Bibliographic Details
Published in:Journal of epidemiology and community health (1979) 2014-05, Vol.68 (5), p.393-395
Main Authors: Becker, Alan, Axelrad, Donald
Format: Article
Language:English
Subjects:
Acids
Arsenic
Arsenic - adverse effects
Carcinogens
Cardiovascular disease
Chemical hazards
Chronic illnesses
Commentary
Community health
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - epidemiology
Dose-Response Relationship, Drug
Drinking water
Drinking Water - chemistry
Environmental Exposure
Family medical history
Gene expression
Humans
Hypertension
Ingestion
Insulin
Insulin resistance
Medical genetics
Meta-analysis
Metabolites
Obesity
Oxidative stress
Population
Population studies
Potable water
Public health
Sample size
Studies
Systematic review
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Urine
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Summary:Approximately 75% of absorbed iAs is excreted in urine as monomethylarsonic acid and dimethylarsinic acid. 36 Using total urinary arsenic is a major limitation because arsenobetaine is excreted after ingestion of various seafoods and should not be included in the iAs exposure assessment in urine. 36 While it would be nice to demonstrate a cause and effect relationship at low levels related to T2DM and iAs, is it necessary? Besides the associations in numerous population studies that iAs increases T2DM, it is also a carcinogen. 39 It is obvious that exposure of populations to iAs in drinking water should be reduced. [...]this study would need a sample size to adequately power the study and would be conducted over several iAs-endemic populations.
ISSN:0143-005X
1470-2738
DOI:10.1136/jech-2013-203463