Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis

Highlights • Grape juice exerts anti-inflammatory potential against colitis. • Grape juice decreases TNF-alpha expression. • Grape juice may be a suitable agent against inflammatory bowel disease.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.819-827
Main Authors: Marchi, Patrícia, Paiotti, Ana Paula Ribeiro, Neto, Ricardo Artigiani, Oshima, Celina Tizuko Fujiyama, Ribeiro, Daniel Araki
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Beverages
Colitis - chemically induced
Colitis - drug therapy
Colitis - immunology
Colitis - pathology
Colon - drug effects
Colon - immunology
Colon - pathology
Comet Assay
Cyclooxygenase 2 - immunology
DNA Damage - drug effects
Emergency
Fruit
Grape juice
Inflammatory bowel disease
Male
Nitric Oxide Synthase Type II - immunology
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats, Wistar
TNBS-colitis
Trinitrobenzenesulfonic Acid
Tumor Necrosis Factor-alpha - immunology
Vitis
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Description
Summary:Highlights • Grape juice exerts anti-inflammatory potential against colitis. • Grape juice decreases TNF-alpha expression. • Grape juice may be a suitable agent against inflammatory bowel disease.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2014.02.006