In vitro effects of omega -3 fatty acids on neutrophil intracellular calcium homeostasis and receptor expression for FMLP and LTB sub(4)

Diets enriched in omega -3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca super(2+) concentration, (Ca super(2+)) sub(i), are important for PMN activation and are in part regulated by membrane Ca super(2+) ATPases. Since membrane...

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Bibliographic Details
Published in:Inflammation 1988-01, Vol.12 (5), p.475-490
Main Authors: Georgilis, K, Klempner, MS
Format: Article
Language:English
Online Access:Get full text
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Summary:Diets enriched in omega -3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca super(2+) concentration, (Ca super(2+)) sub(i), are important for PMN activation and are in part regulated by membrane Ca super(2+) ATPases. Since membrane proteins are influenced by their lipid environment, the authors investigated the in vitro effects of the omega -3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the (Ca super(2+)) sub(i) of PMNs in response to f-Met-Leu-Phe (FMLP), leukotriene B sub(4) (LTB sub(4)), and ionomycin.
ISSN:0360-3997