Frequency and evolution of thin-capped fibroatheromas in left main coronary artery as assessed by serial virtual histology intravascular ultrasound analysis

The objective of the current study was to assess thin-capped fibroatheroma (TCFA) of the left main coronary artery (LMCA) and its changes after statin therapy. We assessed the frequency and distribution of virtual histology intravascular ultrasound (VH-IVUS) thin-capped fibroatheroma (VH-TCFA) in th...

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Bibliographic Details
Published in:The Journal of invasive cardiology 2014-04, Vol.26 (4), p.175-179
Main Authors: Kim, Sang-Wook, Mintz, Gary S, Weissman, Neil J, Lee, Wang Soo, Senguttuvan, Nagendra Boopathy, Kwon, Jee Eun, Kim, Hyangkyoung, Seo, Jae Seung, Seok, Ju Won, Kim, Eun Young, Hyeon, Seong Hyeop, Hong, Joon Hwa, Kim, Chee Jeong, Cho, Dai Yun, Kim, Tae Ho
Format: Article
Language:English
Subjects:
Aged
Atorvastatin Calcium
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - drug therapy
Coronary Artery Disease - epidemiology
Coronary Vessels - diagnostic imaging
Female
Follow-Up Studies
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Incidence
Male
Middle Aged
Phenotype
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - drug therapy
Plaque, Atherosclerotic - epidemiology
Pyrroles - therapeutic use
Quinolines - therapeutic use
Registries
Retrospective Studies
Simvastatin - therapeutic use
Ultrasonography, Interventional - methods
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Summary:The objective of the current study was to assess thin-capped fibroatheroma (TCFA) of the left main coronary artery (LMCA) and its changes after statin therapy. We assessed the frequency and distribution of virtual histology intravascular ultrasound (VH-IVUS) thin-capped fibroatheroma (VH-TCFA) in the LMCA in 500 patients. Serial VH-IVUS examinations were available in 50 patients at 12-month follow-up. The incidence of LM-TCFA was 8.8% (44/500). IVUS LMCA length was longer in patients with VH-TCFA vs without VH-TCFA. Reference external elastic membrane (EEM) area was similar, but reference lumen area and minimal lumen area were smaller in LMCA with VH-TCFA vs without VH-TCFA (P
ISSN:1557-2501