Cross-presentation by human dendritic cell subsets

Highlights • Murine DC subsets can be classified in several lineages that differ in their phenotype and functional properties, in particular in their ability to cross-present antigens. • In humans, distinct DC subpopulations have also been identified. Comparative transcriptomic analysis suggests hom...

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Bibliographic Details
Published in:Immunology letters 2014-03, Vol.158 (1), p.73-78
Main Authors: Segura, Elodie, Amigorena, Sebastian
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigens - immunology
Antigens - metabolism
Biological Evolution
CD8+ T cells
Cell Differentiation
Cell Lineage
Cross-presentation
Cross-Priming
Dendritic cells
Dendritic Cells - immunology
Gene Expression Profiling
Humans
Mice
Vaccination
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Summary:Highlights • Murine DC subsets can be classified in several lineages that differ in their phenotype and functional properties, in particular in their ability to cross-present antigens. • In humans, distinct DC subpopulations have also been identified. Comparative transcriptomic analysis suggests homology between mouse and human DC lineages. • The intracellular mechanisms involved in cross-presentation are conserved between mouse and human DCs, but the specialization of one lineage over others is not.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.12.001