Preparation and characterization of in-situ crosslinked pectin-gelatin hydrogels

Crosslinked hydrogels were developed by in-situ reaction of periodate oxidized pectin (OP) and gelatin. The reaction takes place through the formation of Schiff bases between aldehyde groups of OP and amino groups of gelatin. The effect of various process parameters such as reaction time, reaction t...

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Bibliographic Details
Published in:Carbohydrate polymers 2014-06, Vol.106, p.312-318
Main Authors: GUPTA, Bhuvanesh, TUMMALAPALLI, Mythili, DEOPURA, B. L, ALAM, M. S
Format: Article
Language:English
Subjects:
Applied sciences
Biocompatible Materials - chemistry
Cross-Linking Reagents - chemistry
Exact sciences and technology
Gelatin - chemistry
Glycerol - chemistry
Hydrogels - chemistry
Hydrogen-Ion Concentration
Materials Testing
Microscopy, Electron, Scanning - methods
Natural polymers
Oxidation-Reduction
Pectins - chemistry
Periodic Acid - chemistry
Physicochemistry of polymers
Plasticizers - chemistry
Pliability
Proteins
Schiff Bases - chemical synthesis
Spectroscopy, Fourier Transform Infrared
Starch and polysaccharides
Temperature
Tensile Strength
Viscosity
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Summary:Crosslinked hydrogels were developed by in-situ reaction of periodate oxidized pectin (OP) and gelatin. The reaction takes place through the formation of Schiff bases between aldehyde groups of OP and amino groups of gelatin. The effect of various process parameters such as reaction time, reaction temperature, pH of the reaction and composition on the efficacy of the crosslinking was investigated. Field emission scanning electron micrsocopy (FESEM) revealed that homogenous, single phase systems are obtained after the crosslinking of OP and gelatin. The swelling characteristics of the hydrogels were monitored. The equilibrium swelling varies in the range of 195-324% with a variation in the gelatin content (10-40%). Glycerol, when used as a plasticizer, improved the flexibility and the handling characteristics of the crosslinked hydrogels. Plasticized films retained good tensile strengths in the range of 19-48 MPa. By proper selection of the reaction conditions, the efficiency of crosslinking can be controlled to obtain the optimum results.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2014.02.019