Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)

Abstract PGRMC1 function is implicated in maintaining fetal membrane (FM) integrity. PGRMC1 was detectable primarily in the cytoplasm of FM cells and was actively regulated in FMs and relevant for PGRMC1-mediated progesterone action. By cell type, PGRMC1 expression was higher in amnion and chorion c...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2014-05, Vol.35 (5), p.331-333
Main Authors: Feng, L, Antczak, B.C, Lan, L, Grotegut, C.A, Thompson, J.L, Allen, T.K, Murtha, A.P
Format: Article
Language:English
Subjects:
Amnion - metabolism
Biological and medical sciences
Chorion - metabolism
Decidua - metabolism
Embryology: invertebrates and vertebrates. Teratology
Expression
Extraembryonic Membranes - metabolism
Female
Fetal membrane cells
Fetal Membranes, Premature Rupture - metabolism
Fundamental and applied biological sciences. Psychology
Gestational Age
Humans
Internal Medicine
Membrane Proteins - metabolism
Obstetrics and Gynecology
PGRMC1
PPROM
Pregnancy
Receptors, Progesterone - metabolism
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Summary:Abstract PGRMC1 function is implicated in maintaining fetal membrane (FM) integrity. PGRMC1 was detectable primarily in the cytoplasm of FM cells and was actively regulated in FMs and relevant for PGRMC1-mediated progesterone action. By cell type, PGRMC1 expression was higher in amnion and chorion compared with decidua. By clinical phenotype, PGRMC1 expression was higher among preterm-no-labor and term-no-labor subjects compared to PPROM. PGRMC1 expression appears to be diminished in PPROM subjects.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2014.03.008