High‐dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: A case report

A 15‐yr‐old boy presented with an anterior mediastinal mass, multiple lung metastases and obstruction of the left brachiocephalic vein, the superior vena cava and the subclavian vein. Tumor biopsy by CT guidance confirmed a diagnosis of GCT. Five courses of BEP therapy were performed, and CT of the...

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Bibliographic Details
Published in:Pediatric transplantation 2014-03, Vol.18 (2), p.E52-E56
Main Authors: Keino, Dai, Kondoh, Kensuke, Murata, Shunsuke, Ohyama, Ryo, Morimoto, Mizuho, Muto, Shinji, Fukuda, Miho, Wakisaka, Munechika, Kitagawa, Hiroaki, Kinoshita, Akitoshi
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
autologous peripheral stem cell transplantation
Biopsy
Brachiocephalic Veins - pathology
Diffusion Magnetic Resonance Imaging
Fluorodeoxyglucose F18 - chemistry
high‐dose chemotherapy
Humans
lung metastasis
Lung Neoplasms - immunology
Lung Neoplasms - therapy
Magnetic Resonance Imaging
Male
Neoplasm Metastasis
Neoplasms, Germ Cell and Embryonal - immunology
Neoplasms, Germ Cell and Embryonal - therapy
Peripheral Blood Stem Cell Transplantation - methods
Positron-Emission Tomography
primary mediastinal germ cell tumor
Prognosis
Recurrence
Subclavian Vein - pathology
Tomography, X-Ray Computed
Treatment Outcome
Vena Cava, Superior - pathology
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Summary:A 15‐yr‐old boy presented with an anterior mediastinal mass, multiple lung metastases and obstruction of the left brachiocephalic vein, the superior vena cava and the subclavian vein. Tumor biopsy by CT guidance confirmed a diagnosis of GCT. Five courses of BEP therapy were performed, and CT of the chest revealed reduction in the anterior mediastinal mass and disappearance of the multiple lung metastases. We performed the anterior mediastinal mass extraction followed by adjuvant chemotherapy consisting of ICE and TIP. However, the AFP levels became elevated soon after. Abnormal accumulation was observed in the right upper lung by DW‐MRI. After the operation, two courses of TI chemotherapy and two courses of HDCT followed by auto‐PBSCT were performed. He was complicated with auditory disorder and renal dysfunction. Although HDCT followed by auto‐PBSCT was effective for the relapsed primary mediastinal GCT, a treatment strategy avoiding late complications is warranted.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12210