Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration

Highlights • We studied SNAP25 and VAMP1/2 distribution in adult and newborn deep cerebellar nuclei (DCN). • We tested whether E2 affected PSD95 and synaptic density in developing DCN. • SNAP25, VAMP1/2 distribution in adult DCN differs from that found in newborn DCN. • E2 changes PSD95 localization...

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Bibliographic Details
Published in:Neuroscience 2014-04, Vol.266, p.102-115
Main Authors: Manca, P, Mameli, O, Caria, M.A, Torrejón-Escribano, B, Blasi, J
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Blotting, Western
Cerebellar Nuclei - drug effects
Cerebellar Nuclei - growth & development
Cerebellar Nuclei - metabolism
deep cerebellar nuclei
estradiol
Estradiol - pharmacology
Fluorescent Antibody Technique
Microscopy, Confocal
Neurogenesis - drug effects
Neurogenesis - physiology
Neurology
Rats
Rats, Wistar
SNARE proteins
Synapses - drug effects
Synapses - metabolism
Synaptosomal-Associated Protein 25 - biosynthesis
Vesicle-Associated Membrane Protein 1 - biosynthesis
Vesicle-Associated Membrane Protein 2 - biosynthesis
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Summary:Highlights • We studied SNAP25 and VAMP1/2 distribution in adult and newborn deep cerebellar nuclei (DCN). • We tested whether E2 affected PSD95 and synaptic density in developing DCN. • SNAP25, VAMP1/2 distribution in adult DCN differs from that found in newborn DCN. • E2 changes PSD95 localization and increases synaptic density during DCN development. • SNAP25, VAMP1/2 distribution is age-related; E2 alters synaptic density/proteins in newborn DCN.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.02.008