Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R

Highlights • S. Gallinarum outbreak strains and the SG9R vaccine have identical DNA fingerprints. • Whole-genome sequencing shows 9 SNPs distinguishing an outbreak strain from SG9R. • Mutations in the aceE and rfaJ genes could explain the reversion to virulence of SG9R.

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Bibliographic Details
Published in:Vaccine 2013-10, Vol.31 (43), p.4940-4945
Main Authors: Van Immerseel, F, Studholme, D.J, Eeckhaut, V, Heyndrickx, M, Dewulf, J, Dewaele, I, Van Hoorebeke, S, Haesebrouck, F, Van Meirhaeghe, H, Ducatelle, R, Paszkiewicz, K, Titball, R.W
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Applied microbiology
Bacteriology
Biological and medical sciences
Chickens
Data processing
disease control
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Electrophoresis, Gel, Pulsed-Field
flocks
Fundamental and applied biological sciences. Psychology
gene deletion
genes
Genes, Bacterial
Genome, Bacterial
Genotype
laying hens
lipopolysaccharides
Microbiology
Minisatellite Repeats
Miscellaneous
Molecular Typing
mortality
mutants
Mutation
phenotype
point mutation
Polymorphism, Single Nucleotide
Poultry Diseases - microbiology
pulsed-field gel electrophoresis
pyruvate dehydrogenase (lipoamide)
Reversion
Salmonella enterica
Salmonella enterica - classification
Salmonella enterica - genetics
Salmonella enterica - isolation & purification
Salmonella enterica subsp. enterica serovar Gallinarum
Salmonella Gallinarum
Salmonella Infections, Animal - microbiology
Salmonella Vaccines
sequence analysis
Sequence Analysis, DNA
serotypes
Vaccine
vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
virulence
Whole genome sequencing
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Description
Summary:Highlights • S. Gallinarum outbreak strains and the SG9R vaccine have identical DNA fingerprints. • Whole-genome sequencing shows 9 SNPs distinguishing an outbreak strain from SG9R. • Mutations in the aceE and rfaJ genes could explain the reversion to virulence of SG9R.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.08.033