The effectiveness of the polysaccharide pneumococcal vaccine for the prevention of hospitalizations due to Streptococcus pneumoniae community-acquired pneumonia in the elderly differs between the sexes: Results from the Community-Acquired Pneumonia Organization (CAPO) international cohort study

Highlights • We modeled the effectiveness of a pneumococcal vaccine for patients with pneumonia. • Prevention of hospitalization due to Streptococcus pneumoniae pneumonia was modeled. • The effectiveness of the polysaccharide pneumococcal vaccine was 37% ( P = 0.01). • However, the overall effective...

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Bibliographic Details
Published in:Vaccine 2014-04, Vol.32 (19), p.2198-2203
Main Authors: Wiemken, Timothy L, Carrico, Ruth M, Klein, Sabra L, Jonsson, Colleen B, Peyrani, Paula, Kelley, Robert R, Aliberti, Stefano, Blasi, Francesco, Fernandez-Gonzalez, Ricardo, Lopardo, Gustavo, Ramirez, Julio A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Allergy and Immunology
Applied microbiology
Bacteriology
Biological and medical sciences
Case-Control Studies
Cohort Studies
Community-Acquired Infections - prevention & control
Female
Fundamental and applied biological sciences. Psychology
Hospitalization
Humans
Immunology
Logistic Models
Male
Microbiology
Miscellaneous
Odds Ratio
Pneumococcal Vaccines - therapeutic use
Pneumococcus
Pneumonia, Pneumococcal - prevention & control
Sex differences
Sex Factors
Streptococcus pneumoniae
Vaccine effectiveness
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccinology
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Summary:Highlights • We modeled the effectiveness of a pneumococcal vaccine for patients with pneumonia. • Prevention of hospitalization due to Streptococcus pneumoniae pneumonia was modeled. • The effectiveness of the polysaccharide pneumococcal vaccine was 37% ( P = 0.01). • However, the overall effectiveness was driven by sex differences. • The vaccine was effective in females (68%, P = 0.001) but not in males (34%, P = 0.06).
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.02.048